Endocrine Abstracts

Introduction: Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2B (MEN2B) syndrome is associated with RET mutation. Patients harbouring de novo mutations are usually diagnosed in more advanced stages of the disease. We present the case of a young female patient with MEN2B diagnosed with stage IV medullary thyroid carcinoma at the age of 10 years.Aim: Characterizing the efficacy of the different sequences of therapies and disease pro...

Introduction: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis. In recent years, two prognostic scoring systems incorporating relevant clinicopathological features of ACC (ENSAT stage, grade, resection status, age at diagnosis, tumour symptoms) have been proposed: the GRAS and S-GRAS scoring systems. The prognostic value of these systems has been demonstrated in large, multicentre studies.Aim: To su mmarize the clinicopathological f...

Introduction: Adrenocortical carcinoma (ACC) is a rare tumor known for its diverse biological behaviour and generally poor prognosis. Recently, the S-GRAS scoring system has emerged as an accurate prognostic model, incorporating the most frequently used clinicopathological parameters: ENSAT stage, grade, resection status, age at diagnosis, and tumor symptoms. So far, this system’s efficacy has only been validated in extensive multicenter studies, proposing it as a reliabl...